Increased disease activity in a patient with sarcoidosis after high dose interleukin 2 treatment for metastatic renal cancer
Identifieur interne : 001E68 ( Main/Exploration ); précédent : 001E67; suivant : 001E69Increased disease activity in a patient with sarcoidosis after high dose interleukin 2 treatment for metastatic renal cancer
Auteurs : T F Logan [États-Unis] ; E S Bensadoun [États-Unis]Source :
- Thorax [ 0040-6376 ] ; 2005-07.
English descriptors
- KwdEn :
- Teeft :
- Bone scan, Carcinoma, Case history, Case report, Cell cancer, Creatinine, Creatinine level, Critical care medicine, Cytokine, Granulomatous, Granulomatous inflammation, High dose, High dose treatment, Hydroxychloroquine, Hypercalcaemia, Important role, Inflammation, Metastatic, Nonnecrotising granulomatous inflammation, Pathogenesis, Predominant pattern, Protein level, Sarcoidosis, Sarcoidosis patients, Total calcium.
Abstract
Sarcoidosis is a disease of unknown aetiology in which cytokines such as interleukin 2 (IL-2) are thought to play an important role. We present the case history of a 48 year old man with sarcoidosis who received treatment with high dose IL-2 for metastatic renal cell cancer, following which he developed hypercalcaemia characterised by a raised level of 1,25-dihydroxyvitamin D (1,25-(OH)2-D3), a finding consistent with sarcoidosis associated hypercalcaemia. The increased activity in his sarcoidosis following IL-2 treatment provides direct supportive evidence for the role of IL-2 in the pathogenesis of sarcoidosis.
Url:
DOI: 10.1136/thx.2004.024018
Affiliations:
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We present the case history of a 48 year old man with sarcoidosis who received treatment with high dose IL-2 for metastatic renal cell cancer, following which he developed hypercalcaemia characterised by a raised level of 1,25-dihydroxyvitamin D (1,25-(OH)2-D3), a finding consistent with sarcoidosis associated hypercalcaemia. The increased activity in his sarcoidosis following IL-2 treatment provides direct supportive evidence for the role of IL-2 in the pathogenesis of sarcoidosis.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Indiana</li><li>Kentucky</li></region></list><tree><country name="États-Unis"><region name="Indiana"><name sortKey="Logan, T F" sort="Logan, T F" uniqKey="Logan T" first="T F" last="Logan">T F Logan</name></region><name sortKey="Bensadoun, E S" sort="Bensadoun, E S" uniqKey="Bensadoun E" first="E S" last="Bensadoun">E S Bensadoun</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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